钱吉 教授 Ji Qian, Associate Professor

Ji Qian, PhD

The Executive Director of Biotechnology Center of Fudan University, the Vice President of Fudan-Taizhou Institute of Health Science and a research fellow of Fudan-Zhuhai Institute of Innovation.   A young fellow of the Committee of Cancer Molecular Marker in China Anticancer Association. The Executive Director of the Precision Medicine Branch of China Health Management Association.

Dr. Qian has directed and participated in more than 10 research items, including those approved by Natural Science Foundation of China, "863" Project, "973" Project, Special Project for Precision Medicine, which was established by Ministry of Science and Technology of China, and several items from Shanghai Key Research and Development Project. Dr. Qian has published more than 120 academic papers, 10 of which were published in top-level journals, such as Nature, Nature Genetics, AJHG, and PLOS Genetics in the area of genetics. As the head of Biotechnology Center of Fudan University, his main responsibility is to research and develop novel biomedical techniques, especially gene testing, editing and therapeutic techniques, and to translate them into to FDA-approved diagnostic and therapeutic products.

Publications:

1: Ji Q, Li H, Cai Z, Yuan X, Pu X, Huang Y, Fu S, Chu L, Jiang C, Xue J, Zhang X, Li R. PYGL-mediated glucose metabolism reprogramming promotes EMT phenotype and metastasis of pancreatic cancer. Int J Biol Sci. 2023 Mar 21;19(6):1894-1909. doi: 10.7150/ijbs.76756. PMID: 37063425; PMCID: PMC10092766.

2: He Y, Shi J, Zhao H, Wang Y, Zhang C, Han S, He Q, Li X, Li S, Wang W, Yi M, Hu X, Xing Z, Han H, Gao Y, Zhou Q, Lu L, Guo J, Cao H, Lu C, Hou Y, Chen D, Yang F, Lei P, Di W, Qian J, Xia Y, Zhang Y, Deng Y, Zhu J, Xu C. p16INK4A flow cytometry of exfoliated cervical cells: Its role in quantitative pathology and clinical diagnosis of squamous intraepithelial lesions. Clin Transl Med. 2023 Mar;13(3):e1209. doi: 10.1002/ctm2.1209. PMID: 36881611; PMCID: PMC9991008.

3: Chen L, Qian J, You Q, Ma J. LIM domain-containing 2 (LIMD2) promotes the progress of ovarian cancer via the focal adhesion signaling pathway. Bioengineered. 2021 Dec;12(2):10089-10100. doi: 10.1080/21655979.2021.2000732. PMID: 34724866; PMCID: PMC8809939.

4: Shi TY, Yang G, Tu XY, Yang JM, Qian J, Wu XH, Zhou XY, Cheng X, Wei Q. RAD52 variants predict platinum resistance and prognosis of cervical cancer. PLoS One. 2012;7(11):e50461. doi: 10.1371/journal.pone.0050461. Epub 2012 Nov 29. PMID: 23209746; PMCID: PMC3510183.

5: Li H, Cai X, Winograd-Cort ER, Wen B, Cheng X, Qin Z, Liu W, Liu Y, Pan S, Qian J, Tan CC, Jin L. Mitochondrial DNA diversity and population differentiation in southern East Asia. Am J Phys Anthropol. 2007 Dec;134(4):481-8. doi: 10.1002/ajpa.20690. PMID: 17668442.

6: Wang X, Lu M, Qian J, Yang Y, Li S, Lu D, Yu S, Meng W, Ye W, Jin L. Rationales, design and recruitment of the Taizhou Longitudinal Study. BMC Public Health. 2009 Jul 10;9:223. doi: 10.1186/1471-2458-9-223. PMID: 19589173; PMCID: PMC2715397.

7: Ji F, Wang W, Xia ZL, Zheng YJ, Qiu YL, Wu F, Miao WB, Jin RF, Qian J, Jin L, Zhu YL, Christiani DC. Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers. Carcinogenesis. 2010 Apr;31(4):648-53. doi:10.1093/carcin/bgq015. Epub 2010 Jan 25. PMID: 20100738; PMCID: PMC3499047.

8: Qian J, Qu HQ, Yang L, Yin M, Wang Q, Gu S, Wu Q, Zhao X, Wu W, Wu J, Tan X, Chen W, Wang H, Wang J, Fan W, Chen H, Han B, Lu D, Wei Q, Jin L. Association between CASP8 and CASP10 polymorphisms and toxicity outcomes with platinum-based chemotherapy in Chinese patients with non-small cell lung cancer. Oncologist. 2012;17(12):1551-61. doi: 10.1634/theoncologist.2011-0419. Epub 2012 Jul 27. PMID: 22843554; PMCID: PMC3528388.

9: Zhong Y, Huang Y, Huang Y, Zhang T, Ma C, Zhang S, Fan W, Chen H, Qian J, Lu D. Effects of O6-methylguanine-DNA methyltransferase (MGMT) polymorphisms on cancer: a meta-analysis. Mutagenesis. 2010 Jan;25(1):83-95. doi: 10.1093/mutage/gep050. Epub 2009 Nov 5. PMID: 19892775.

10: Wang S, Zhao Y, Ruan Z, Chen H, Fan W, Chen J, Wu Q, Qian J, Zhang T, Huang Y, Lu D. Association between EGF +61 G/A and glioma risk in a Chinese population. BMC Cancer. 2010 May 21;10:221. doi: 10.1186/1471-2407-10-221. PMID: 20487573; PMCID: PMC2885363.

11: Gan RJ, Pan SL, Mustavich LF, Qin ZD, Cai XY, Qian J, Liu CW, Peng JH, LiSL, Xu JS, Jin L, Li H; Genographic Consortium. Pinghua population as an exception of Han Chinese's coherent genetic structure. J Hum Genet. 2008;53(4):303-313. doi: 10.1007/s10038-008-0250-x. Epub 2008 Feb 13. PMID: 18270655.

12: Jiang DK, Wu X, Qian J, Ma XP, Yang J, Li Z, Wang R, Sun L, Liu F, Zhang P,Zhu X, Wu J, Chen K, Conran C, Zheng SL, Lu D, Yu L, Liu Y, Xu J. Geneticvariation in STAT4 predicts response to interferon-α therapy for hepatitis B eantigen-positive chronic hepatitis B. Hepatology. 2016 Apr;63(4):1102-11. doi:10.1002/hep.28423. Epub 2016 Feb 19. PMID: 26704347.

13: Qian J, Gu S, Wu Q, Zhao X, Wu W, Gao Z, Zhang W, Tan X, Wang H, Wang J, FanW, Chen H, Han B, Lu D, Wei Q, Jin L. Association of CASP7 polymorphisms andsurvival of patients with non-small cell lung cancer with platinum-basedchemotherapy treatment. Chest. 2012 Sep;142(3):680-689. doi:10.1378/chest.11-2522. PMID: 22441531.

14: Qian J, Jing J, Jin G, Wang H, Wang Y, Liu H, Wang H, Li R, Fan W, An Y, SunW, Wang Y, Ma H, Miao R, Hu Z, Jin L, Wei Q, Shen H, Huang W, Lu D. Associationbetween polymorphisms in the GSTA4 gene and risk of lung cancer: a case-controlstudy in a Southeastern Chinese population. Mol Carcinog. 2009Mar;48(3):253-259. doi: 10.1002/mc.20478. PMID: 18767114.

15: Xue F, Wang Y, Xu S, Zhang F, Wen B, Wu X, Lu M, Deka R, Qian J, Jin L. Aspatial analysis of genetic structure of human populations in China revealsdistinct difference between maternal and paternal lineages. Eur J Hum Genet.2008 Jun;16(6):705-17. doi: 10.1038/sj.ejhg.5201998. Epub 2008 Jan 23. PMID:18212820.

16: Li R, Yang Y, An Y, Zhou Y, Liu Y, Yu Q, Lu D, Wang H, Jin L, Zhou W, QianJ, Shugart YY. Genetic polymorphisms in DNA double-strand break repair genesXRCC5, XRCC6 and susceptibility to hepatocellular carcinoma. Carcinogenesis.2011 Apr;32(4):530-6. doi: 10.1093/carcin/bgr018. Epub 2011 Feb 8. PMID:21304054.

17: Wu W, Zhang W, Qiao R, Chen D, Wang H, Wang Y, Zhang S, Gao G, Gu A, Shen J,Qian J, Fan W, Jin L, Han B, Lu D. Association of XPD polymorphisms with severetoxicity in non-small cell lung cancer patients in a Chinese population. ClinCancer Res. 2009 Jun 1;15(11):3889-95. doi: 10.1158/1078-0432.CCR-08-2715. Epub2009 May 19. PMID: 19458053.

18: Qiu YL, Wang W, Wang T, Liu J, Sun P, Qian J, Jin L, Xia ZL. Geneticpolymorphisms, messenger RNA expression of p53, p21, and CCND1, and possiblelinks with chromosomal aberrations in Chinese vinyl chloride-exposed workers.Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2578-84. doi:10.1158/1055-9965.EPI-07-2925. PMID: 18842998.

19: Chen J, Ji C, Gu S, Zhao E, Dai J, Huang L, Qian J, Ying K, Xie Y, Mao Y.Isolation and identification of a novel cDNA that encodes human yrdC protein. JHum Genet. 2003;48(4):164-9. doi: 10.1007/s10038-002-0001-3. Epub 2003 Mar 1.PMID: 12730717.

20: Lu J, Zhang S, Chen D, Wang H, Wu W, Wang X, Lei Y, Wang J, Qian J, Fan W,Hu Z, Jin L, Shen H, Huang W, Wei Q, Lu D. Functional characterization of apromoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancersusceptibility. FASEB J. 2009 Oct;23(10):3459-69. doi: 10.1096/fj.09-136549.Epub 2009 Jun 18. PMID: 19541747.

21: Zhao X, Wang X, Wu W, Gao Z, Wu J, Garfield DH, Wang H, Wang J, Qian J, LiH, Jin L, Li Q, Han B, Lu D, Bai C. Matrix metalloproteinase-2 polymorphisms andclinical outcome of Chinese patients with nonsmall cell lung cancer treated withfirst-line, platinum-based chemotherapy. Cancer. 2012 Jul 15;118(14):3587-98.doi: 10.1002/cncr.26669. Epub 2011 Nov 9. PMID: 22072145.

22: Li R, Shugart YY, Zhou W, An Y, Yang Y, Zhou Y, Zhang B, Lu D, Wang H, QianJ, Jin L. Common genetic variations of the cytochrome P450 1A1 gene and risk ofhepatocellular carcinoma in a Chinese population. Eur J Cancer. 2009May;45(7):1239-1247. doi: 10.1016/j.ejca.2008.11.007. Epub 2008 Dec 26. PMID:19110417.

23: Zan Q, Wen B, He Y, Wang Y, Xu S, Qian J, Lu D, Jin L. Complete sequencedata support lack of balancing selection on PRNP in a natural Chinesepopulation. J Hum Genet. 2006;51(5):451-454. doi: 10.1007/s10038-006-0383-8.Epub 2006 Mar 25. PMID: 16565881.

24: Li H, Huang Y, Mustavich LF, Zhang F, Tan JZ, Wang LE, Qian J, Gao MH, JinL. Y chromosomes of prehistoric people along the Yangtze River. Hum Genet. 2007Nov;122(3-4):383-8. doi: 10.1007/s00439-007-0407-2. Epub 2007 Jul 27. PMID:17657509.

25: Wen B, Li H, Lu D, Song X, Zhang F, He Y, Li F, Gao Y, Mao X, Zhang L, QianJ, Tan J, Jin J, Huang W, Deka R, Su B, Chakraborty R, Jin L. Genetic evidencesupports demic diffusion of Han culture. Nature. 2004 Sep 16;431(7006):302-5.doi: 10.1038/nature02878. PMID: 15372031.

26: Li R, Ji Q, Fu S, Gu J, Liu D, Wang L, Yuan X, Wen Y, Dai C, Li H. ITGA3promotes pancreatic cancer progression through HIF1α- and c-Myc-drivenglycolysis in a collagen I-dependent autocrine manner. Cancer Gene Ther. 2025Feb;32(2):240-253. doi: 10.1038/s41417-024-00864-7. Epub 2024 Dec 17. PMID:39690180.